GO:0033173 biological_process calcineurin-NFAT signaling cascade
| PAG Title | GO:0033173 biological_process calcineurin-NFAT signaling cascade |
| PAG ID | TAX022016 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,367 |
| Information Content | Rich |
| Other IDs | GO:0033173 |
| Base PAG ID | TAX022016 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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